The range of possible sample contaminants, variability in starting material, & range of possible reagents for sample preparation has resulted in variability in data generated from mass spectrometry. Current methodologies and tools for sample clean-up prior to digestion and MS analysis require the use of in-line column chromatography, desalting columns/membranes, and/or packed tips for partitioning. Although some of these techniques are broadly applicable, they are not routinely automatable, or don’t provide the option for parallel processing required for high-throughput. In order to fully automate clean-up we have developed a versatile magnetic mixed-mode HILIC with broad applicability for the removal of common contaminants required in the solubilization and denaturation of proteins. The automation of sample processing using magnetic beads reduces sample handling, and providing massively parallel sample processing, and improves reproducibility.
MagReSyn® HILIC provides a highly reproducible and fully automatable solution for parallel protein sample clean-up prior to MS analysis. The product is compatible with a range of common contaminants which interfere in the generation of high quality data from MS analysis of samples.
Please review our extensive range of application notes and posters to see how MagReSyn® HILIC can be used for your sample preparation.
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