Drug target identification

Got a drug that induces the wanted phenotype but have no idea what it's target is? Use the combined power of medicinal chemistry and mass spectrometry to discover the target of your drug.

Drug target ID workflow

Modify, crosslink and identify

Identifying the target of a drug can seem to be a hard process. And it is. However, using a clever combination of medicinal chemistry, well-designed protocol and mass spectrometry greatly enhances your chances of success. Here's how we proceed:

  1. Assist in the synthesis of your drug with reactive groups (if needed);
  2. Design the experiment based on your insights;
  3. Perform the experiment in 3 steps:
    1. Incubate the drug and crosslink;
    2. Purify the drug/target complex from the protein solution;
    3. Analyze the complex using LC-MS/MS and identify the target.

As a side note, using a quantitative proteomics workflow enables to get clearer insights in the real target of the drug, as it is compatible with dose-response experiments. This is why we design the protocols in accordance with our label-free quantitative proteomics workflow.

Data report

Provided information for drug-target identification data reports includes the raw and analyzed data as well as a list of the most probable targets of the studied drug. Additionally, an in-depth explanation on what qualifies the proteins in the list as potential targets will be offered.

Contact us discuss about your drug target ID experiment

"PhenoSwitch Bioscience Inc has provided us with outstanding efficacious service, high quality data and exemplary data analysis over the past three years."

Stephen Naylor, Ph.D., CEO at ReNeuroGen LCC, Milwaukee, USA
"They have provided excellent data in a timely manner on a number of metabolism and protein studies ongoing in my group"
Klaus Klarskov, Ph.D., Professor at Université de Sherbrooke, Canada
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